TESTS & LABS FOR Chronic Fatigue Syndrome

In addition to the tests you may have already done with your doctor or other practitioner, here are additional tests I may want to order us to see exactly what’s going on. Chronic Fatigue Syndrome (CFS) has many layers. This is where testing comes in. I use a variety of different tests for understanding the root causes of CFS.

All tests below can be obtained directly through myself if you’re a client of mine.

1. Custom Blood Panel from Quest or LabCorp

    • CMV IgG + IgM
    • HHV6 IgM
    • TSH + Total T4 + Total T3 + Free T4 + Free T3 + Reverse T3 + T3 Uptake + TPO & Thyroglobulin Antibodies
    • Serum Iron + Ferritin + Total Iron Binding Capacity
    • Serum zinc, copper, and ceruloplasmin
    • Hemoglobin A1C
    • Immunoglobulins A/E/G/M
    • C-Reactive Protein
    • alpha MSH
    • Vitamin D Complex (25 OH + 1,25)
    • Parathyroid hormone
    • Complete Blood Count + Comprehensive Metabolic Panel

This custom blood panel will give us an overview of many different body systems, as well as let us know if reactivated Epstein-Barr, Cytomegalovirus, Human Herpes Virus 6, thyroid dysfunction, iron imbalance, inflammation, immune deficiency, mineral imbalances, mycotoxin/mold illness, vitamin D deficiency, and/or blood sugar imbalances are part of the underlying imbalances causing CFS in you.

Take at your nearest LabCorp or Quest, whichever you prefer.

Part of this test may be covered by insurance if you go through your doctor or primary care provider. Print & take to your provider: Custom Blood Panel with Codes

2. Salivary test

  • 4x Cortisol
  • DHEA-S

This important test will let us know if adrenal fatigue a.k.a. HPA axis dysfunction is contributing to how you feel. My favorite version of this test is called the “201A” by BioHealth Laboratory.

At-home test.

3.   Lyme + Co-Infection Testing

Testing for Lyme and co-infections can get a bit tricky. The pathogens can hide incredibly well, making many tests produce false negatives. Not only that, but there are multiple different strains of Borrelia that are connected to Lyme disease. Common tests only test for one of these (Borrelia Burgorferi).

Global Lyme Diagnostics offers a test that checks antibodies to the outer surface protein that’s common in all Borrelia species. Not only does this test provide a look into whether someone is infected with the Borrelia species, they also offer a co-infection panel that includes Anaplasma, Erlichia, Babesia duncani, Babesia microti, Bartonella henselae, Bartonella quintana, and Rickettsia.

This test is done by a mobile phlebotomist or at your nearest lab that will do blood draws for Global Lyme Diagnostics (unfortunately Quest and LabCorp will not do draws for other labs). We will figure out your easiest option together.

As Lyme testing can get expensive and it’s not always necessary, I prefer combining a thorough case history + the Horowitz Lyme Questionnaire to see how you score before we do more extensive testing for Lyme + co-infections. Lyme can also closely mimic reactivated Epstein-Barr.

4. Organic Acids + Heavy Metals + Environmental Toxins + Mycotoxins (Mold)

As you can see this is actually 4 tests in one, but it’s done with a single urine sample making it very simple to do. This 4-in-1 test shows us the state of mitochondrial efficiency, B vitamin status, yeast/candida overgrowth, clostridia bacteria overgrowth, blocked detoxification or methylation pathways, fatty acid metabolism, heavy metal toxicity, mineral deficiencies, environmental toxins, mold toxins, and more. I like to get this “4 in 1” test from Great Plains Laboratory. It includes the following: Organic Acids Test, GPL-TOX, MYCOTOX Profile, and Metals Urine Test.

At-home test.

5. GI-MAP + Zonulin

This stool test shows us a comprehensive look at what’s going on in your gut that may be contributing to the bigger picture of CFS:

  • Parasitic infections
  • Bacterial infections
  • Viral infections
  • Bacterial overgrowth
  • Yeast overgrowth
  • Occult blood
  • b-Glucoronidase
  • Leaky gut
  • Immunity (sIgA & anti-gliadin IgA)
  • Inflammation (calprotectin)
  • Absorption/assimilation (elastase & fecal fat)

My favorite stool test which includes the above markers is called the “GI-MAP + zonulin” by Diagnostic Solutions Laboratory.

At-home test.

6. MARCoNS + Fungal Culture

This nasal swab will let us know if MARCoNS and/or a fungal infection of the sinuses is part of your CFS. MARCoNS is an antibiotic-resistant bacterial colonization in the sinuses of many with CFS, and a fungal infection of the sinuses can emit mycotoxins that can directly cause CFS. MARCoNS and fungal infections can exist separately or together.

At-home test.

7. Elimination Diet

Although not a lab test, an elimination diet is an incredibly important part of recovering from CFS. Food sensitivities can greatly contribute to your overall inflammation levels and immunity. Specific fermentable carbohydrates (like FODMAPS) may be contributing to yeast and bacterial overgrowth in your gut. I prefer to target your elimination diet based on your symptoms and initial lab results.

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